Clinical study of gemcitabine combined with radiotherapy in the treatment of elderly patients with advanced cervical cancer
- VernacularTitle:吉西他滨联合放疗治疗老年中晚期宫颈癌的临床研究
- Author:
Gailing FU
- Publication Type:Journal Article
- Keywords:
gemcitabine;
radiation therapy;
elderly advanced cervical cancer;
adverse reaction
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;(2):128-129,132
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efifcacy and adverse reactions of gemcitabine combined with radiotherapy in the treatment of elderly patients with advanced cervical cancer. Methods 80 elderly patients with advanced cervical cancer in the First Affiliated Hospital of Henan University of Science and Technology from June 2009 to Febrary 2012 were selected and randomly divided into control group(n=40) and observation group(n=40). Control group was given radiotherapy, while observation group was given gemcitabine combined with radiotherapy. The clinical efifcacy, incidences of adverse reactions and quality of life between two groups were compared. Results The total effective rates in 6 weeks after treatment were signiifcantly better than 1 week in both two groups(P<0.05), but there was no difference between two groups. The quality-of-life scores in observation group were signiifcantly higher than control group(P<0.05), but the incidence of adverse reactions in observation group was also signiifcantly higher than control group(P<0.05). Conclusion Gemcitabine combined with radiotherapy in the treatment of elderly patients with advanced cervical cancer has better clinical efifcacy and patients could enjoy a better quality of life, but it has a higher incidence of adverse reactions, so this combination therapy should depend on the speciifc situation of patients.
