Influence of percutaneous coronary intervention on plasma levels of monocyte chemotactic factor-1 and interlekin-6 in patients with coronary heart disease
10.3969/j.issn.1008-0074.2013.02
- VernacularTitle:冠状动脉介入治疗对冠心病血浆单核细胞趋化因子-1和白细胞介素-6水平的影响
- Publication Type:Journal Article
- Keywords:
Coronary artery disease;
Chemotactic factors;
Interlekin-6
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2013;22(2):146-149
- CountryChina
- Language:English
-
Abstract:
Objective: To investigate influence of percutaneous coronary intervention (PCI) on inflammatory indexes and postoperative vascular restenosis in patients with coronary heart disease (CHD) through measuring plasma levels of monocyte chemotactic factor-1 (MCP-1) and interlekin-6 (IL-6) before and after PCI. Methods: A total of 60 CHD patients undergoing PCI with single vessel coronary disease were consecutively enrolled as PCI group, and 30 subjects with normal coronary artery proved by coronary angiography (CAG) were regard as normal control group. Enzyme linked immunosorbent assay (ELISA) was used to measure plasma MCP-1 and IL-6 levels before and after PCI，CAG in PCI group，normal control group respectively. Results: Compared with before PCI, there were significant increase in plasma levels of MCP-1 [(17.38±4.58) pg/L vs. (20.51±4.61) pg/L] and IL-6 [(14.59±4.62) pg/ml vs. (18.87±4.92) pg/ml] after operation in PCI group (P<0.01 both). There were no significant difference in MCP-1 and IL-6 levels in normal control group before and after CAG (P>0.05). The MCP-1 and IL-6 levels after PCI in PCI group were significant more than those of normal control group after CAG (P<0.05). Conclusion: Plasma levels of MCP-1（plays a core regulative role in inflammatory reaction）and IL-6（a central adjustment factor in inflammatory response）increased in patients with coronary heart disease after PCI, suggesting MCP-1 and IL-6 correlate with in-stent restenosis after PCI．
- Full text:P020130514500130300572.doc
