The Principles of Diagnosing Suspected Vaccination Related Death and Application the Principles to the Four Cases of Suspected Vaccination related Deaths
- VernacularTitle:疑似预防接种死亡的死因排查原则及其在4起疑似接种疫苗后死亡死因排查中的初步应用
- Author:
Jiatong ZHUO
- Publication Type:Journal Article
- Keywords:
Vaccination;
Death;
Differentiation principles
- From:
Chinese Journal of Vaccines and Immunization
2008;0(06):-
- CountryChina
- Language:Chinese
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Abstract:
Objective To explore the practical principles in diagnosis of suspected vaccination related deaths.Method Collection information of four suspected vaccination related deaths,including clinic symptom,vaccination history,autopsy and final diagnosis.Analyzing and hypothesis of possible cause of death to exclude vaccine allergy and vaccine quality without enough attenuation and opened ample contaminated with bacterium and its toxin or performance error based on theory of allergy and regulations of vaccine producing quality and the vaccination management process combined with epidemiological survey.Results None of death caused by vaccination which were testified based on the four principle(1)the onset time longer than 2 hour after vaccination excluded from allergy,(2)cases not with the same batch of the vaccine or the patient without the symptom and the similar duration of incubation of the vaccine target disease to excluded from vaccine quality;(3)vaccine ample not opened long time before vaccination excluded from vaccine contaminated with bacterium and its toxin(4)not similar pharmaceutical agent put at the same place with the vaccine during vaccination excluded from the performance error.Conclusion The four principles in diagnosis of suspected vaccination related death was scientific,objective,practical,feasible and helpful in the investigation of suspected vaccination related death,especially for those who working in the grass-root such as county immunization management institute or township hospital.
