Study on the antitumor activity and antioxidation of polysaccharide from Gracilaria lemaneiformis in sarcoma180 bearing mice
- VernacularTitle:龙须菜多糖抑瘤活性及对荷瘤小鼠抗氧化作用的研究
- Publication Type:Journal Article
- Keywords: Gracilaria Lemaneiformis; polysaccharide; S180; antioxidation
- From: Chinese Journal of Marine Drugs 1994;0(02):-
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the effects of antitumor and antioxidation of polysaccharide from Gracilaria Lemaneiformis(PGL) in sarcoma180 bearing mice.Methods The PGL extracted with hot water was administered to Sarcoma180 mice,then the superoxide dismutase(SOD) activity in red blood cell and lipoperoxide(LPO) content of liver homogenate of Sarcoma180mice were determined to estimate the antioxidant effect of PGL. Results PGL could significantly inhibit the growth of Sarcoma180 in mice.At the dose of 150mg?kg-1,ig,the inhibition rate was 63.56%.PGL obviously decreased LPO content of liver homogenate in Sarcoma180 mice.Conclusion The polysaccharide from Gracilaria Lemaneiformis could increase the antioxidant effect of Sarcoma180 mice,and it may be one of the mechanisms to realize its antitumor activivy.