Identification of HLA alleles with psoriatic members in a Chinese family
- VernacularTitle:一寻常型银屑病家系的HLA等位基因分析
- Publication Type:Journal Article
- Keywords: psoriasis; human leucocyte antigens(HLA); haplotypes; family studies
- From: Basic & Clinical Medicine 2006;0(03):-
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the correlation of HLA class I and II alleles in a Northern Chinese Family members with psoriasis vulgaris.Methods The polymerase chain reaction amplification with sequence-specific oligonucleotide probe(PCR-SSO) method was used to analyze the alleles of HLA-A,B,DRB1 in all the family members.Results HLA-B*13-DRB1*07 was identified as a high-risk haplotype in four early-onset psoriatic members(Ⅱ-2,Ⅱ-4,Ⅲ-1,Ⅲ-5)(age of onset