Effect of piperine for preventing on delayed cerebral vasospasm following experimental subarachnoid hemorrhage in rabbit
- VernacularTitle:胡椒碱预防实验性家兔SAH后迟发性脑血管痉挛
- Author:
Gengshen ZHANG
- Publication Type:Journal Article
- Keywords:
delayed cerebral vasospasm;
endothelial nitricoxide synthase(eNOS);
endothelin-1(ET-1);
piperine;
subarachnoid hemorrhage
- From:
Basic & Clinical Medicine
2006;0(04):-
- CountryChina
- Language:Chinese
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Abstract:
Objective To observe whether piperine has the ability to prevent delayed cerebral vasospasm(DCVS) after subarachnoid hemorrhage(SAH).Methods Thirty-two New Zealand white rabbits were divided into four groups randomly(n=8).Group A(shamed-injecting blood): Puncture was completed without injecting blood into the cisterna magna;Group B(SAH): DCVS model was made with two-hemorrhage of SAH by injecting autologous arterial blood into the cisterna magna;Group C(SAH + piperine): Piperine(piperine(20 mg/kg),solvent(0.5 mL/kg)) was intravenously administrated daily since day 0 after first injection.Group D(SAH+DMSO): The solvent((0.5 mL/kg)) was gave by i.v.for DCVS models.All animals were sacrificed at day 7 after the first injection.The internal diameter and D/T(internal diameter/wall thickness) values of basilar artery(BA) were measured.The expression of ET-1 and eNOS in arterial wall of BA at day 7 was collected via immunohistochemistry method.Results The severe vasospasm of BA,over expression of ET-1 and diminished expression of eNOS in group B were found vs group A.The vasospasm of BA in group C was obviously alleviated in comparison with it in group B and D,respectively(P
