The Therapeutic Effects of AFP Gene-Modified Dendritic Cell-Based Tumor Vaccine by Different Re-Infused Pathways
- VernacularTitle:不同途径免疫的AFP基因修饰DC瘤苗体内抗肿瘤效应的研究
- Publication Type:Journal Article
- Keywords: dendritic cell; alpha-fetoprotein; hepatoma Hepal-6 cells; tumor vaccine; gene therapy
- From: Chinese Journal of Cancer Biotherapy 1994;0(01):-
- CountryChina
- Language:Chinese
- Abstract: Objective: To observe the anti-tumor effects of adenovirus earring AFP gene transfected DC using different inculabe administrations. Methods: The immunotherapy effects of AFP-DC vaccine were compared among administration of intra-vein, hypo-dermal and intra-tumor. The protective and therapeutic effects of AFP-DC tumor vaccine were detected by 4 h 51Cr releasing assay and depleting T cells and NK cells. Results: The therapentic effect of Hypo-dermal was significantly better than assays of the other two ways in inhibiting tumor growth and prolonging the survival period of the mice(P