Efficacy of COAPROVEL for primary hypertension compared with HYZAAR
- VernacularTitle:安博诺和海捷亚治疗原发性高血压的疗效比较
- Author:
Guolan DEND
- Publication Type:Journal Article
- Keywords:
Coaprovel;
Hyzaar;
Primary hypertension;
Efficacy;
Security
- From:
Journal of Chongqing Medical University
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the efficacy,security and tolerance of COAPROVEL(150mg Irbesartan and 12.5mg Hydrochlorothia zide per tablet) and HYZAAR(150mg Losartan and 12.5mg Hydrochlorothiazide per tablet)for primary hypertension.Methods:A total of 48 primary hypertensive patients of signed informed consent were enrolled,and required to stop all antihypertensive and vasoactive drugs.Their average systolic blood pressure(SBP) was between 140 ～180mmHg and average diastolic blood pressure(DBP) between 95 ～ 115mmHg by three times' detection of sitting posture.According to the order which patients were brought into groups patients were randomized,COAPROVEL group and HYZAAR group,each with 24 persons.Those in the treatment group were given one tablet of COAPROVEL for 4 wk at 7am to 8am in the morning,while others were given one tablet of HYZAAR as the control group.Blood pressure,heart rate,liver function,renal function,glucose,lipids and electrolyte were observed before and after treatment and adverse effect incidence rate of the medicine was also observed.Results:BP declined significantly in both groups at 2 wk and 4 wk of drug aministration treatment(P0.05).Contemporarily,no prominent side effects were found in two groups.Conclusion:Both COAPROVEL and HYZAAR are effectively antihypertensive.COAPROVEL provides greater decline of blood pressure with the same security and tolerance than with HYZAAR.
