Long-Term Outcome of Cystic Lesions in the Pancreas: A Retrospective Cohort Study.
- Author:
Dong Won AHN
1
;
Sang Hyub LEE
;
Jaihwan KIM
;
Won Jae YOON
;
Jin Hyeok HWANG
;
Jin Young JANG
;
Ji Kon RYU
;
Yong Tae KIM
;
Sun Whe KIM
;
Yong Bum YOON
Author Information
1. Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea. yyb10604@plaza.snu.ac.kr
- Publication Type:Original Article
- Keywords:
Pancreatic cyst;
Natural history;
Prognosis
- MeSH:
Cohort Studies;
Follow-Up Studies;
Humans;
Natural History;
Pancreas;
Pancreatic Cyst;
Prognosis;
Retrospective Studies
- From:Gut and Liver
2012;6(4):493-500
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: The management guidelines for cystic lesions of the pancreas (CLPs) are not yet well established. This study was performed to document the long-term clinical outcome of CLPs and provide guidelines for the management and surveillance of CLPs. METHODS: In this retrospective cohort study, an additional follow-up was performed in 112 patients with CLPs enrolled from 1998 to 2004 during a previous study. RESULTS: During follow-up for the median period of 72.3 months, the size of the CLPs increased in 18 patients (16.1%). Six of these patients experienced growth of their CLPs after 5 years of follow-up. Twenty-six patients underwent surgery during follow-up, and four malignant cysts were detected. The overall rate of malignant progression during follow-up was 3.6%. The presence of mural nodules or solid components was independently associated with the presence of malignant CLPs. Seven patients underwent surgery after 5 years of follow-up. The pathologic findings revealed malignancies in two patients. There was only one pancreas-related death during follow-up. CONCLUSIONS: The majority of CLPs exhibit indolent behavior and are associated with a favorable prognosis. However, long-term surveillance for more than 5 years should be performed because of the potential for growth and malignant transformation in CLPs.
