Assessment of Intermediate Coronary Stenosis in Koreans Using the Fractional Flow Reserve.
10.4070/kcj.2008.38.9.468
- Author:
Keun Ho PARK
1
;
Bon Kwon KOO
;
Jung Won SUH
;
Hae Young LEE
;
Jin Shik PARK
;
Hyun Jae KANG
;
Young Seok CHO
;
Woo Young CHUNG
;
Tae Jin YOUN
;
In Ho CHAE
;
Dong Ju CHOI
;
Hyo Soo KIM
;
Byung Hee OH
;
Young Bae PARK
Author Information
1. Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, Cardiovascular Center, Seoul National University Hospital, Seoul, Korea. bkkoo@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Coronary stenosis;
Fractional flow reserve, myocardial;
Stents
- MeSH:
Constriction, Pathologic;
Coronary Angiography;
Coronary Stenosis;
Decision Making;
Disease-Free Survival;
Follow-Up Studies;
Fractional Flow Reserve, Myocardial;
Glycosaminoglycans;
Humans;
Incidence;
Male;
Myocardial Infarction;
Stents
- From:Korean Circulation Journal
2008;38(9):468-474
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Previous studies that used physiologic parameters have shown that coronary angiography is not always accurate in the evaluation of intermediate lesions. We sought to evaluate the outcomes of Korean patients for whom revascularization was deferred according to their fractional flow reserve (FFR). SUBJECTS AND METHODS: FFR was measured in 107 intermediate lesions (visually estimated percent stenosis: 40-70%) in 102 consecutive patients (68% males, mean age: 62+/-9 years). The one-year cardiac adverse outcomes (cardiac death, myocardial infarction or target vessel revascularization) of all the patients and the long-term outcomes of the patients for whom revascularization was deferred according to the FFR were evaluated. RESULTS: The mean percent diameter stenosis was 57+/-11% and the FFR was 0.82+/-0.10. Only 25 lesions (23%) had a FFR <0.75. There was no significant difference in the 1-year cardiac event rates between the FFR > or =0.75 group and the FFR <0.75 group (10.4% vs. 13.0%, respectively, p=0.49). There was a tendency of a lower incidence of 1-year cardiac events in the medical treatment group than in the revascularizaton group (8.0% vs. 20.0%, respectively, p=0.10). In the 69 patients with FFR-guided deferral of revascularization, the long-term (mean follow-up duration: 41+/-11 months) cardiac event-free survival rate was 86%. CONCLUSION: The measurement of FFR seems to be a useful guide for decision making and it may reduce unnecessary intervention in Korean patients who suffer with intermediate stenosis.
