Moderate diet-induced weight loss is associated with improved insulin sensitivity in middle-aged healthy obese Korean women.
- Author:
Hye Ok LEE
1
;
Jung Eun YIM
;
Young Seol KIM
;
Ryowon CHOUE
Author Information
- Publication Type:Original Article
- Keywords: Oderate weight loss; beta-cell function and insulin sensitivity
- MeSH: Adipose Tissue; Area Under Curve; Blood Glucose; Blood Pressure; Body Weight; C-Peptide; Caloric Restriction; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Fasting; Female; Glucose; Glucose Tolerance Test; Hip; Humans; Insulin; Insulin Resistance*; Leptin; Triglycerides; Waist Circumference; Weight Loss*
- From:Nutrition Research and Practice 2014;8(4):469-475
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/OBJECTIVE: The goal of the present study was to investigate the effects of moderate caloric restriction on beta-cell function and insulin sensitivity in middle-aged obese Korean women. SUBJECTS/METHODS: Fifty-seven obese pre-menopausal Korean women participated in a 12-week calorie restriction program. Data on total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglycerides (TG), and fasting serum levels of glucose, insulin, C-peptide, blood pressure, leptin and anthropometrics were collected. A dietary intake assessment was based on three days of food recording. Additionally, beta-cell function [homeostasis model assessment of beta-cell (HOMA-beta), insulinogenic index (ISI), C-peptide:glucose ratio, and area under curve insulin/glucose (AUCins/glu)] and insulin sensitivity [homeostasis model assessment for insulin resistance (HOMA-IR), Quantitative insulin-sensitivity check index (QUICKI) and Matsuda index (MI)] were recorded. RESULTS: When calories were reduced by an average of 422 kcal/day for 12 weeks, BMI (-2.7%), body fat mass (-10.2%), and waist circumference (-5%) all decreased significantly (P < 0.05). After calorie restriction, weight, body fat percentage, hip circumference, BP, TC, HDL-C, LDL-C, plasma glucose at fasting, insulin at fasting and 120 min, AUCglu and the insulin area under the curve all decreased significantly (all P < 0.05), while insulin sensitivity (HOMA-IR, QUICKI and Matsuda index) measured by OGTT improved significantly (P < 0.01). CONCLUSIONS: Moderate weight loss due to caloric restriction with reduction in insulin resistance improves glucose tolerance and insulin sensitivity in middle-aged obese women and thereby may help prevent the development of type 2 diabetes mellitus.
