THYROXINE INSUFFICIENCY AND RETARDATION OF BRAIN MYELINATION
- VernacularTitle:甲状腺激素合成不足与脑髓化障碍
- Author:
Zmpei CHEN
- Publication Type:Journal Article
- Keywords:
Myelination Cerebroside Hypothyroidism Cretinism
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The iodine deficient rats fed on low iodine diet demonstrated hypothyroidism with low T3 and T4, and high TSH. Cholesterol content of whole brain tissues in deficient rats at 20 days of age was significantly lower than that of the control, and cerebroside and lipidprotein also markedly decreased. These changes were even more obvious in cerebellum than in cerebrum. However, there was no difference in cerebroside content between the two groups at 42 days of age. The results indicated that retardation of brain myelination and delay in myelinogenesis might be related to thyroxine insufficiency and change in cerebroside was a reversible process.
