THE EFFECT OF PHOSPHATE-LOAD ON URINARY PROTEIN EXCRETION IN DIABETICS
- VernacularTitle:磷负荷对糖尿病患者尿蛋白排泄的影响
- Author:
Zhiguangdept ZHOU
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus Phosphate-load Urinary protein excretion
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(01):-
- CountryChina
- Language:Chinese
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Abstract:
The effect of phosphate-load (PL) on urinary protein excretion (UPE) was observed in 14 NIDDM patients without azotemia. All of the patients were with conventional anti-diabetic treatment (CAT). Significant increase of UPE by PL was observed in controlled diabetics (n = 6) with CAT for four weeks, whereas in uncontrolled diabetics with CAT (n = 8) a decrease of UPE was observed. Net increment of urinary phosphate excretion in controlled diabetics was 70% more than that in uncontrolled diabetics after PL. These findings demonstrated that excessive dietary phosphate play a role of nephrotoxicity, and also suggested that hyperphosphaturia was involved in the development of pro-teinuria in diabetics. The problem of appropriate supplement of phosphate for diabetics was discussed.
