FUNCTIONAL CHANGES OF HYPOTHALAMUS, ANTERIOR PITUITARY, THYROID, AND ADRENAL CORTEX IN EHF AND THEIR CLINICAL SIGNIFICANCE
- VernacularTitle:流行性出血热下丘脑-垂体、甲状腺、肾上腺皮质功能的变化及其意义
- Author:
Zhijiandept SUN
- Publication Type:Journal Article
- Keywords:
Epidemic hemorrhagic fever Prolactin Growth hormone Cortisol Thyrotropin Thyroid hormones
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The functions of hypothalamus, anterior pituitary, thyroid, and adrenal cortex were studied in 299 cases with epidemic hemorrhagic fever (EHF). It was found that the serum PRL, GH, TSH and plasma cortisol were significantly higher at early stage and returned to normal when diuresis occurred. Pituitary function tests showed that the hypo-thalamic-pituitary-adrenocortical axis and prolactin secretion were intact, while the hypothalamic-pituitary-thyroid axis and GH secretion were somewhat impaired. In severe cases there were low T3 syndrome associated with increased rT3 level.We concluded that the augmented secretion of PRL, GH, cortisol and catecholamines may be due to a stress which, might be responsible for the insulin resistance and decreased immunological function. Therefore, the use of immune-potentiating agents, insulin, and drugs such as phentolamine, propranolol might be beneficial.
