CHARACTERISTICS OF SUBJECTS WITH IGT AND ITS CORRELATION WITH CORONARY HEART DISEASE
- VernacularTitle:糖耐量低减的特征及其与冠心病发生的关联
- Author:
Xiaoren PAN
- Publication Type:Journal Article
- Keywords:
Impaired glucose tolerance Coronary heart disease
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Among 280,000 population aged 25-74 years in Da Qing, 108, 600 persons were surveyed for diabetes in 1 986. According to WHO criteria (1980), 596 (5.5‰) persons with impaired glucose tolerance (IGT) and 630 (5.8‰) new diabetics were diagnosed in addition to 190(1.7‰) diabetics known. In comparison to age-sex-matched controls with normal oral glucose tolerance test, hypertension(35.3%), obesity (BM1≥25, 61%) and rate of microalbuminurea excretion were twice as common in IGT as in controls. The prevalence of hyperlipoproteinemia were higher in IGT than that in controls, IGT had a prevalence of coronary heart disease 8.9 times greater than did controls. Although IGT had hyperinsulinemia, one-hour IRI (insulin mU/L: blood glucose mmol/L) after 75g glucose load were lower in IGT than that in controls. Therefore IGT had both insulin resistance and impaired function of islet.Non-symptomatic slight hyperglycemic state itself in IGT was a risk factor for CHD, which was independent of age, hyperlipoproteinemia, hypertension and obesity.
