ULTRASTRUCTURAL CHANGES OF MYOCARDIAL CELLS IN PATIENTS WITH ADVANCED MALIGNAT TUMORS BEFORE AND AFTER ADMINISTRATION OF ADRIAMYCIN
- VernacularTitle:晚期恶性肿瘤患者阿霉素疗程前后心肌的亚微结构改变
- Author:
Jindisn CHEN
- Publication Type:Journal Article
- Keywords:
adriamycin;
malignant tumors;
ultrastructural cnanges;
myocardial cells
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
In order to investigate the myocardial changes in patients with malignant tumors in the late stage before and after adriamycin(ADR)administration, the electron microscopic observation and comparison of 5 cases (osteosarcoma 2, fibrosarcoma 1, liver carcinoma 1, malignant lymphoma 1) were conduced. The changes of myocardial cells before ADR administration are: (1) distension of sarcoplasmic reticulum and some T-tubules: vacuolar dilatation of some intercalated discs; the local area of the sarcolemma defects, (2) hyperplastic mitochondria witn swelling, (3) focal myofibrillar loss and numerous lipofuscin granules in the cytoplasm. The changes after ADR administration were the same as those before administration, but more prominent. In addition, some mitochondria botn of their external and internal membranes were all lysed and disappeared. Only a group of cristae were remained. According to our observation, the myocardial cells before ADR administration have some submicroscopic changes. These changes may be produced by some toxic metabolites in the patients. Our sstudies suggest that the cnanges are a latent crisis for the patient, although they are only a ubclinical phenomenon.
