Clinical Observation of Medroxyprogesterone or Dydrogesterone Combined with Hysteroscopic Electrosur-gery in the Treatment of Early Estrogen-dependent Endometrial Cancer
10.6039/j.issn.1001-0408.2016.21.10
- VernacularTitle:甲羟孕酮与地屈孕酮分别联合宫腔镜电切术治疗早期雌激素依赖型子宫内膜癌的临床观察
- Author:
Zhenge ZHANG
- Publication Type:Journal Article
- Keywords:
Dydrogesterone;
Medroxyprogesterone;
Hysteroscopic electrosurgery;
Early estrogen-dependent endometrial can-cer;
Efficacy;
Safety
- From:
China Pharmacy
2016;27(21):2910-2912
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the efficacy and safety of medroxyprogesterone or dydrogesterone combined with hystero-scopic electrosurgery in the treatment of early estrogen-dependent endometrial cancer. METHODS:42 patients with early estro-gen-dependent endometrial cancer were randomly divided into medroxyprogesterone group (21 cases) and dydrogesterone group (21 cases). All patients received hysteroscopic electrosurgery. Medroxyprogesterone group received 100 mg Medroxyprogesterone acetate tablet,3 times a day. Dydrogesterone group received 100 mg Dydrogesterone tablet,twice a day. The treatment course for both groups was 6 months. Clinical efficacy,carbohydrate antigen CA125(CA125),body mass and the incidence of adverse reac-tions in 2 groups were observed. RESULTS:After 3 months of treatment,the total effective rate in dydrogesterone group was sig-nificantly lower than medroxyprogesterone group,the difference was statistically significant(P<0.05). After 12 months,the total effective rates in 2 groups were significantly higher than 3 months,the difference was statistically significant(P<0.05),but there was no significant difference between 2 groups (P>0.05). Before treatment,there were no significant differences in CA125 and body mass in 2 groups (P>0.05). After 3 and 12 months,CA125 levels in 2 groups were significantly lower than before,12 months was lower than 3 months,and dydrogesterone group was higher than medroxyprogesterone group after 3 months,the differ-ences were statistically significant (P<0.05),but there were no significant differences between 2 groups after 12 months (P>0.05). After treatment,the body mass in medroxyprogesterone group was significantly higher than before,the difference was statis-tically significant (P<0.05);while there was no significant difference in dydrogesterone group before and after treatment (P>0.05). And the incidence of adverse reactions in dydrogesterone group was significantly lower than medroxyprogesterone group,the difference was statistically significant(P<0.05). CONCLUSIONS:The short-term efficacy of medroxyprogesterone combined with hysteroscopic electrosurgery is superior to dydrogesterone combined with hysteroscopic electrosurgery in the treatment of early estro-gen-dependent endometrial cancer,but medroxyprogesterone combined with hysteroscopic electrosurgery shows high incidence of adverse reactions. Long-term effects of both Dydrogesterone and Medroxyprogesterone are equivalent.
