Incretin hormone glucagon-like peptide 1 and gut microbiota
10.3867/j.issn.1000-3002.2016.06.008
- VernacularTitle:胰高血糖素样肽1和肠道菌群
- Author:
Tianru JIN
- Publication Type:Journal Article
- Keywords:
glucagon-like peptide-1,incretins;
L cell models;
microbiota,gut;
short-chain fatty acids
- From:
Chinese Journal of Pharmacology and Toxicology
2016;30(6):691-702
- CountryChina
- Language:Chinese
-
Abstract:
There are more than two dozens of peptide hormones that are produced and released from the gastrointestinal (GI) tract. Among them, the incretin hormone glucagon-like peptide 1 (GLP-1) has received the most intensive attention for the past 30 years. Functional studies on GLP-1 and anoth?er gut incretin hormone glucose-dependent insulinotropic peptide (GIP) have led to the development of novel diabetes therapeutic agents known as GLP-1 receptor agonists and DPP-Ⅵinhibitors. Instead of forming endocrine glands, the gut hormone producing endocrine cells are widely spread throughout the entire GI tract, permitting vital interactions with the″external″environment. Here a brief introduction on GLP-1 and how nutritional components regulate its secretion were made, followed by reviewing some key development on how gut environment affects the production and secretion of GLP-1, including the contribution of gut microbiota.
