Apocrine Carcinoma of the Axilla with Predominant Signet Ring Cell Features A Case Report.
10.4132/KoreanJPathol.2011.45.3.326
- Author:
Jeana KIM
1
;
Tae Eun KIM
;
Ah Won LEE
;
Yeong Jin CHOI
;
Kyo Young LEE
;
Eun Sun JUNG
Author Information
1. Department of Hospital Pathology, The Catholic University of Korea College of Medicine, Seoul, Korea. esjung@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Apocrine glands;
Carcinoma, signet ring cell;
Axilla
- MeSH:
Aged;
Apocrine Glands;
Axilla;
Carcinoma, Signet Ring Cell;
Cytoplasm;
Decapitation;
Dermis;
Eosinophils;
Epithelial Cells;
Humans;
Middle Aged;
Mucins;
Muramidase;
Sweat Glands
- From:Korean Journal of Pathology
2011;45(3):326-328
- CountryRepublic of Korea
- Language:English
-
Abstract:
Apocrine carcinoma arising from the apocrine sweat glands is a rare cutaneous malignant tumor which occurs predominantly in the axilla of elderly individuals. The typical histologic features of apocrine carcinoma is within a well developed glandular lumina with abundant eosinophilic cytoplasm and evidence of decapitation secretion. In rare instances, predominant signet ring cell features in apocrine carcinoma has been reported. We experienced a case that occured in the right axilla of a 59-year-old. Histopathologic examination showed a solid tumor that extended from the upper dermis into the subcutis, with a delicate infiltrate of epithelial cells. The cells had granular amphophilic cytoplasm, predominantly showed distinct signet ring cell morphology, and were strongly positive for epithelial mucin. Both lysozyme and gross cystic disease fluid protein-15 were identified in the tumor cells. We diagnosed this to be a case of primary signet ring cell apocrine carcinoma of the axilla after several immunohistochemical and clinical evaluations.
