Clinical research of edaravone combined with citicoline for the treatment of acute ischemic cerebral infarction
10.3760/cma.j.issn.1008-6315.2015.07.014
- VernacularTitle:依达拉奉联合胞二磷胆碱治疗急性脑梗死临床效果观察
- Author:
Lianming HUANG
- Publication Type:Journal Article
- Keywords:
Edaravone;
Citicoline;
Acute ischemic cerebral infarction
- From:
Clinical Medicine of China
2015;31(7):621-623
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effect of edaravone combined with citicoline for treatment of acute ischemic cerebral infarctio.Methods Eighty-two cases patients of acute cerebral infarction were selected from March 2012 to August 2013 in the General Hospital of XingTai Mining group.According to admission order,they were randomly divided into observation group and control group,and each group of 41 cases.Single blind studies were carried out and on the basis of conventional treatment methods,the control group was given ozagrel sodium 80 mg,2 times/d,continuous 14 days.Observation group applied 30 mg edaravone,2 times/d,continuous 14 days.Besides this,observation group were given citicoline 1 000 mg,ontinuous 14 days.Comparison of therapeutic effects were observed for 14 days.Results Before and after treatment,the national institutes of health stroke scale (NIHSS) score,Barthel index,superoxide dismutase (SOD) of observation group were (14.1±3.2) and (5.1±1.6),(51.6±13.5) and (73.1±15.9),(145.3±32.6) U/L and (226.9± 39.7) U/L,which of control group were (13.7 ± 3.3) and (10.2± 3.0),(53.4± 13.8) and (59.9±14.1),(143.6±33.8) U/L and (179.4±35.7) U/L,and there were significant difference between before and after treatment of two groups(observation group:t=16.108,6.600,10.171,P＜0.01;control group:t =5.025,2.110,4.663,P＜0.05),and between observation group and control group after treatment(t =0.605,3.977,5.697,P＜0.01).Furthermore observation group's total effective rate was 97.6％ (40/41),significantly better than that of control group,and the difference was significant (80.5％ (33/41),x2 =4.49,P ＜0.05).Conclusion It is better that edaravone combined with citicoline for the treatment of acute ischemic cerebral infarction which can effectively protect the brain tissue,improve the patients' neurologic deficits and their ability of daily life.
