Effect and safety of preoperative emergency application tirofiban on percutaneous coronary intervention in STEMI patients
10.3969/j.issn.1008-0074.2015.05.29
- VernacularTitle:STEMI 介入治疗患者急诊提前应用替罗非班的效果及安全性
- Author:
Lin WANG
;
Congquan WANG
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Angioplasty,balloon,coronary;
Tirofiban
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2015;24(5):575-578
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore therapeutic effect and safety of preoperative emergency application tirofiban on per‐cutaneous coronary intervention (PCI) in patients with acute ST elevation myocardial infarction (STEMI) .Methods :A total of 147 STEMI patients ,who received emergency PCI combined tirofiban in our hospital from Dec 2012 to Dec 2013 ,were selected .According to random number table method ,they were divided into emergency tirofiban group (n=76 ,receive tirofiban before PCI ) and routine tirofiban group (n=71 ,received tirofiban after PCI as rou‐tine) .Preoperative antegrade blood flow in infarct related vessels ,postoperative blood flow ,incidence rates of clin‐ical bleeding complications and cardiovascular events within 30d after PCI were compared between two groups .Re‐sults:Compared with routine tirofiban group ,before PCI ,there were significant rise in percentages of TIMI blood flow class 3 (10.0% vs .22.4% ) and class 2+3 (23.9% vs .39.5% ) in emergency tirofiban group , P<0.05 all;there were no significant difference in postoperative TIMI blood flow class 3 ,Blush class 3 ,TIMI frame count and incidence rates of clinical bleeding complications and cardiovascular events within 30d after PCI between two groups , P>0.05 all .Conclusion:Preoperative emergency application tirofiban can improve antegrade blood flow in infarct related vessels before PCI in STEMI patients .
