Influence on Serum Inflammatory Factors Level and Efficacy of Octreotide Combined with Potent Purga-tive Decoction with Additions in Patients with Early Postoperative Inflammatory Bowel Obstruction ( EPIS-BO) after Abdominal Operation
- VernacularTitle:奥曲肽联合复方大承气汤对腹部手术后早期炎性肠梗阻患者血清炎症因子水平的影响及疗效观察
- Author:
Chen SENHUA
- Publication Type:Journal Article
- Keywords:
Early postoperative inflammatory bowel obstruction;
After abdominal operation;
Octreotide;
Potent purgative decoc-tion with additions;
Inflammatory factors
- From:
China Pharmacist
2015;18(10):1744-1746
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss the influence and curative effect of octreotide combined with potent purgative decoction with ad-ditions on serum inflammatory factors level in the patients with early postoperative inflammatory bowel obstruction ( EPISBO) after ab-dominal operation. Methods: Totally 78 cases of patients with EPISBO after abdominal operation were divided into the observation group and the control group with 39 ones in each. The patients in the two groups were given the basic medical treatment, such as fast-ing, water deprivation, gastrointestinal decompression, maintenance of water, electrolyte and acid-base balance, infection prevention, parenteral nutrition support and etc. The patients in the control group were given 0. 1mg octreotide via hypodermic injection, q8h, while the patients in the observation group were additionally given potent purgative decoction with additions, one dose per day comple-ted by twice or three times through mouth or nasogastric tube. The course of treatment was 1 week. The changes of serum hs-CRP and TNF-α levels in the two groups before the treatment and after the medical treatment were observed and compared, and the curative effect and adverse drug reactions ( ADR) were evaluated as well. Results: After the one-week medical treatment, the serum hs-CRP and TNF-α levels in the two groups were obviously declined (P<0. 05 or P<0. 01), and the declining rate in the observation group was much higher than that in the control group (P<0. 05), and the total clinical efficiency in the observation group (94. 87%) was much higher than that in the control group (79. 49%, P<0. 05). Totally 3 and 5 cases of ADR were respectively appeared in the con-trol group and the observation group with mild symptom, and no statistical difference was shown between the two groups (P>0. 05). Conclusion:Octreotide combined with potent purgative decoction with additions has significant curative effect in the patients with EPISBO after abdominal operation with high security, and the mechanisms are related with such effects as reducing serum hs-CRP and TNF-α levels and inhibiting local inflammatory response in intestinal tract.
