The effect analysis of inhaled nitric oxide on the treatment of acute hypoxic respiratory failure
10.3760/cma.j.issn.1673-4904.2014.34.018
- VernacularTitle:吸入一氧化氮辅助治疗急性低氧性呼吸衰竭的效果分析
- Author:
Huaimin WU
;
Jingtai HU
;
Bo ZHOU
- Publication Type:Journal Article
- Keywords:
Respiratory insufficiency;
Infant,newborn;
Nitric oxide;
Blood gas analysis
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(34):54-56
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the effect of inhaled nitric oxide on the treatment of acute hypoxic respiratory failure.Methods One hundred and thirty newborns of acute hypoxic respiratory failure were divided into treatment group and control group with 65 cases each according to the treatment method.Both groups received conventional mechanical ventilation and drug therapy,and the treatment group received inhaled nitric oxide therapy on this basis.The effect,oxygenation index,arteries and alveolar oxygen partial pressure ratio was compared between two groups.All the cases were followed up for 6 months after treatment,and the prognosis including death,complication,etc was observed.Results The total effective rate in treatment group was higher than that in control group [95.4％ (62/65) vs.84.6％ (55/65)],and there was significant difference(P ＜ 0.05).The oxygenation index,arteries and alveolar oxygen partial pressure ratio in treatment group was better than that in control group [(365.38 ± 45.27) mmHg (1 mmHg =0.133 kPa) vs.(267.77 ± 50.33) mmHg,0.38 ± 0.12 vs.0.27 ± 0.10],and there was significant difference (P ＜ 0.05).After 6 months' follow-up,there was no significant difference in mortality between two groups (P ＞ 0.05).The complications rate in treatment group was lower than that in control group [7.7％ (5/65) vs.21.5％ (14/65)],and there was significant difference (P ＜ 0.05).Conclusion Inhaled nitric oxide in adjuvant treatment of acute hypoxic respiratory failure can effectively improve the efficacy and improve prognosis,which may be related with the improvement in blood gas analysis.
