Clinical significance of serum triglyceride and D-dimer in the early diagnosis of fat embolism syndrome after fracture
10.3760/cma.j.issn.1008-6315.2015.01.022
- VernacularTitle:血清甘油三酯及D二聚体检测对早期诊断骨折后脂肪栓塞综合征的临床价值
- Author:
Anyu LUO
- Publication Type:Journal Article
- Keywords:
Fracture;
Lipid;
D-dimer;
Fat embolism syndrome
- From:
Clinical Medicine of China
2015;31(1):70-73
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinic significance of blood lipid and D-dimer in the early diagnosis of fat embolism syndrome (FES) after fracture.Methods Forty-nine cases of fracture complicated with fat embolism syndrome patients and 50 patients with fracture at the same time were selected as our subjects.The levels of serum triglyceride (TG) and D-dimer level were detected.Results Among the FES patients,61.2％ (30/49) were hemoglobin decline,followed by 57.1％ (28/49) with hypoxemia,51.0％ (25/49) with mucous membrane bleeding point,16.3 ％ (8/49) with pulmonary symptoms and 20.4％ (10/49) temperature ＞38℃.The levels of TG level and D-dimer in FES patients were (2.57 ± 0.84) mmol/L and (1758.5 ± 144.2) μg/L,significantly higher than patients without FES ((1.16 ± 0.34) mmol/L,(562.4 ±76.8) μg/L;P =0.000).ROC curve showed that the area under the curve(AUC) of TG in the diagnosis of FES was 68.3％,and the cut-off value was 2.04 mmol/L,with the sensitivity of 66.7％ and the specificity of 63.5％.The AUC of D-dimer was 67.4％,and the cut-off was 1 045.7 μg/L,with the sensitivity of 66.7％ and the specificity of 61.5％.Conclusion There is an important diagnostic value of serum TG and D-dimer in predicting FES after long and pelvic fracture,which can be used as a clinical powerful auxiliary examination in the diagnosis of FES.There is important clinical significance to improve the cure rate and reduce the death of FES.
