Investigation on indicators of bone metabolism in middle-aged male patients with metabolic syndrome
10.3760/cma.j.issn.1673-4904.2013.34.005
- VernacularTitle:中年男性代谢综合征患者骨代谢指标变化研究
- Author:
Zhenghe TANG
- Publication Type:Journal Article
- Keywords:
Middle aged;
Men;
Metabolic syndrome X;
Bone metabolism;
Insulin resistance
- From:
Chinese Journal of Postgraduates of Medicine
2013;36(34):13-16
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of metabolic syndrome (MS) on bone metabolism in middle-aged male patients with MS by measuring indicators of bone metabolism.Methods Among people who underwent physical examination from October 2010 to May 2013,110 middle-aged male patients with MS were selected and enrolled in MS group and 36 middle-aged men without MS were selected and enrolled in non-MS group.In MS group,27 patients with osteoporosis were enrolled in MS with osteoporosis group and 36 patients with decreased bone mass were enrolled in MS with decreased bone mass group.In each group:body mass index (BMI) and homeostasis model assessment for insulin resistance (HOMA-IR) was calculated;systolic blood pressure (SBP),diastolic blood pressure (DBP) and waist circumference was measured;blood biochemical indicators including fasting plasma glucose (FPG),2 h postprandial plasma glucose (2 h PG),fasting insulin (FINS),total cholesterol (TC),triglyceride (TG),low density lipoprotein-cholesterol (LDL-C) and high density hpoprotein-cholesterol (HDL-C) was tested; bone metabolic indicators including serum calcium,phosphate,alkaline phosphatase,25-hydroxy vitamin D [25-(OH)D3],procollagen type Ⅰ amino-terminal prcpeptide (PINP),parathyroid hormone (PTH),osteocalcin and urinary C-terminal telopeptide of type Ⅰ collagen (U-CTX),urine calcium,urine creatinine (Cr) were tested;bone mineral density(BMD) of lumber spine was tested too.Subjects above were compared among the four groups.The correlation of BMD with other bone metabolic indicators and HOMA-IR was also investigated in MS with osteoporosis group.Results The incidence of abnormal bone metabolism in MS group was 57.3％ (63/110),while in non-MS group was 11.1％ (4/36),and there was significant difference between two groups (x2 =6.55,P ＜ 0.01).Compared with non-MS group,MS group,MS with osteoporosis group and MS with decreased bone mass group had significant higher BMI,waist circumference,SBP,D BP,FPG,2 h PG,TC,TG,LDL-C,FINS,HOMA-IR(P ＜ 0.01 or ＜ 0.05) and lower HDL-C (P ＜ 0.01).Compared with non-MS group,MS group,MS with osteoporosis group and MS with decreased bone mass group had lower PINP,25-(OH)D3,osteocalcin and BMD (P ＜0.05 or ＜0.01) and higher PTH,urinary calcium/Cr,U-CTX/Cr(P ＜ 0.05 or ＜ 0.01).There was no significant difference in serum calcium,phosphate and alkaline phosphatase among four groups (P ＞ 0.05).BMD in MS with osteoporosis group was positively correlated with osteocalcin and 25-(OH)D3 (P ＜ 0.05),negatively correlated with PTH,U-CTX/Cr,urinary calcium/Cr and HOMA-IR (P ＜ 0.05).Conclsion Loss of bone mass and osteoporosis in middle-aged male patients with MS is due to decreased bone formation and increased bone absorption,which is closely related to insulin resistance.
