Analysis of influencing factors of liver damage caused by Statins drugs

VernacularTitle:他汀类药物导致肝损害的影响因素分析
Author: Bianfen WEI
Publication Type:Journal Article
Keywords: Statins; Liver injury,drug-induced; Risk factors
From: Chinese Journal of Primary Medicine and Pharmacy 2013;20(15):2288-2289
CountryChina
Language:Chinese
Abstract: Objective To analyze the characteristics and risk factors of hepatic lesion caused by statins drugs,and to provide evidence for prevention.Methods 401 patients using statins were collected,64 cases occurred liver damage.Clinical features and related factors such as age,sex,alcohol,TB category,hepatitis B surface antigen carriers were statistically analyzed.Results In 401 cases,15.96％ of patients occurred liver damage.Statistical analysis showed that the incidence rates of liver function damage in HBsAg (+),weekly drinking ≥ 500g,retreatment,≥60 years old were 41.07％,25.68％,19.67％,26.97％ respectively(all P ＜ 0.05).Sex was not relate with drug induced liver damage(P ＞ 0.05).Conclusion HBsAg(+),alcohol consumption,the retreatment and old TB patients are high-risk groups occurred hepatic dysfunction,which should attract clinical attention.