Clinical analysis of pulmonary surfactant in treatment of 30 cases with neonatal respiratory distress syndrome

VernacularTitle:肺表面活性物质治疗新生儿呼吸窘迫综合征30例临床分析
Author: Wei WANG
Publication Type:Journal Article
Keywords: Pulmonary surfactants; Respiratory distress syndrome; Infant,neonate
From: Chinese Journal of Primary Medicine and Pharmacy 2013;20(17):2592-2593
CountryChina
Language:Chinese
Abstract: Objective To explore the effect of pulmonary surfactant(PS) in the treatment of neonatal respiratory distress syndrome(NRDS).Methods According to whether using the PS,60 NRDS patients were divided into treatment group and control group.The blood-gas analysis index,oxygen time,mechanical ventilation time,hospitalization time and other indicators were analyzed.Results After 6h treatment,blood pH value (7.41 ± 0.11),PaO2 (69.8 ± 11.9) mm Hg and PaCO2 (48.7 ± 11.1)mm Hg in the treatment group were higher than those of the control group (7.24 ±0.13),(53.3 ±9.8)mm Hg,(59.1 ± 12.7)mm Hg(t =3.35,2.88,3.24,all P ＜0.05).In the treatment group,oxygen time (98.2 ± 29.2) h,the time of mechanical ventilation (77.6 ± 30.4) h and hospitalization time (12.9 ± 1.7)d,were also shorter than those of the control group (143.9 ± 26.5) h,(121.4 ± 22.9) h,(17.6 ±2.1) d (t =4.56,5.32,4.86,all P ＜ 0.05).Conclusion The application of PS in the treatment of NRDS can improve the lung function and lung aeration and reduce the time of mechanical ventilation.