Forecasting system on spatial coverage of cumulative phenotypic frequency of HLA class Ⅰ for designing HLA-based vaccines in China
10.3969/j.issn.1000-8861.2005.02.017
- VernacularTitle:中国多表位疫苗设计的HLA-Ⅰ积累表型频率空间预测系统
- Author:
Fuzhong XUE
;
Jiezhen WANG
;
Ping HU
;
Yishou GUO
;
Guorong LI
- Publication Type:Journal Article
- Keywords:
Spatial forecasting system;
Cumulative phenotypic frequency;
HLA-based vaccines;
DNA vaccines
- From:
Immunological Journal
2005;(2):136-141
- CountryChina
- Language:Chinese
-
Abstract:
Objective To build the forecasting system on spatial coverage of cumulative phenotypic frequency (CPF) of HLA- Ⅰ for designing HLA-based vaccines (epitopes or DNA vaccines) and evaluating their effects in China. Methods The spatial database of HLA- Ⅰgenes of Chinese (across the land of China) was set up, and then the spatial forecasting system of CPF was designed using Kriging technique.Results Using this spatial forecasting system, the vaccine designer could predict the spatial coverage of CPF for any combination of the alleles confined to a single class Ⅰ locus, either HLA-A or HLA-B, as well as for any combination of alleles at these two loci of each given population at any geographical location across the land of China. Conclusions This system is applicable in the following rields: ①To provide for the identification of alleles that represent a desired percentage of populations across the land of China and that can be targeted for vaccine composition. ② To predict the theoretical responder status of vaccines whose HLA restricted epitopes have already been known in given population at any geographical location across the land of China. (③) To identify how many individuals will be non-responders to a HLA-based vaccine across the land of China.
