Variation and clinical significance of serum cardiac troponin I and interleukin-6 in patients with acute organophosphorus pesticide poisoning
10.3760/cma.j.issn.1673-4904.2012.27.009
- VernacularTitle:急性有机磷农药中毒患者血清心肌肌钙蛋白I和白细胞介素6水平的改变及临床意义
- Author:
Xueshou LIU
- Publication Type:Journal Article
- Keywords:
Troponin I;
Interleukin-6;
Acute organophosphorus pesticide poisoning
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(27):26-28
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the variation and clinical significance of serum cardiac troponin I (cTnI) and interleukin-6 (IL-6) in patients with acute organophosphorus pesticide poisoning (AOPP).Methods The serum cTnI and IL-6 levels in 97 patients with AOPP(AOPP group) and 40 healthy subjects (control group) were tested by double antibody sandwich enzyme linked immunosorbent assay and compared between two groups.Results The serum cTnI and IL-6 levels in AOPP group on admission,admission 1,3 d were respectively (2.51 ± 0.80),(2.11 ± 0.67 ),( 1.58 ± 0.50) μ g/L and ( 154.82 ± 49.15 ),( 139.33 ± 44.23),(108.37 ± 34.40) ng/L,which were higher than those in control group [(0.02 ± 0.01 )μ g/L,(82.61 ± 26.23) ng/L] (P ＜ 0.05).The serum cTnI and IL-6 levels increased with increasing degrees of poisoning.The different degrees of poisoning was positively correlated with the serum cTnI and IL-6 levels (r =0.642,0.517,P ＜ 0.05).Conclusions The degrees of poisoning,myocardial damage and inflammatory reaction of AOPP patients are closely related to the serum cTnI and IL-6 levels.The dynamic observation of the serum cTnI and IL-6 levels has an important significance for the judging the severity of myocardial damage and inflammatory reaction of AOPP patients.
