The signal-regulated networks of HIF-1α in hippocampus region after epileptic seizures
10.3760/cma.j.issn.1673-4408.2012.05.024
- VernacularTitle:癫(癎)发作后海马区低氧诱导因子-1α表达的信号调节网络
- Author:
Shiguang HUO
- Publication Type:Journal Article
- Keywords:
Epilepsy;
HIF-1 α;
Signaling pathway
- From:
International Journal of Pediatrics
2012;39(5):513-517
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia-inducible factor-1(HIF-1) is a key factor in hypoxic response of cells.It plays an important role in embryonic development,cerebral infarction,cerebral hemorrhage,hypoxic-ischemic encephalopathy,neurodegenerative diseases,cancers and other physiological or pathological processes.Studies have confirmed that in developing rats,the expression of HIF-1 α mRNA and HIF-1α in hippocampus after status epilepsy enhanced obviously,and it is related to proliferation of neural stem cells.Although some experiments have explored the relationship between certain signaling pathways and HIF-1 α,no experiments come to the signal-regulation in the expression of HIF-1α after epilepsy.
