The neuroprotective effect of colloids in forebrain ischemia model.
- Author:
Hye Min SOHN
1
;
Young Tae JEON
;
Jung Won HWANG
;
Hee Pyoung PARK
;
Young Jin LIM
;
Sun Hye KANG
Author Information
1. Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. ytjeon@snubh.org
- Publication Type:Original Article
- Keywords:
Albumin;
Brain ischemia;
Hippocampus;
Pentastarch
- MeSH:
Animals;
Brain Ischemia;
Carotid Artery, Common;
Colloids;
Hetastarch;
Hippocampus;
Humans;
Hypotension;
Ischemia;
Male;
Neuroprotective Agents;
Prosencephalon;
Pyramidal Cells;
Rats;
Rats, Sprague-Dawley
- From:Anesthesia and Pain Medicine
2012;7(4):338-342
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The aim of this study was to investigate the neuroprotective effects of colloids (albumin and pentastarch) after forebrain global ischemia in rats. METHODS: Thirty male Sprague-Dawley rats were randomly assigned to three groups; control, albumin and pentastarch group (each n = 10). Forebrain ischemia was induced by bilateral common carotid artery occlusion plus hemorrhagic hypotension. The control group received no treatment. The albumin group received 5 ml/kg of 20% albumin after ischemia. The pentastarch group received same volume of albumin after ischemia. Histologic outcomes were measured at 7 days after ischemia in CA1 pyramidal cells of the rat hippocampus. RESULTS: The mean percentage of viable cells in the hippocampal CA1 area was significantly higher in the albumin (47%) compared with the control group (33%) or pentastarch group (33%) (P = 0.001). The percentage of apoptotic cells was significantly lower in the albumin (30%) group than that in the pentastarch (44%) or control group (49%) (P = 0.006). CONCLUSIONS: This study shows that albumin can improve histologic outcomes after forebrain global ischemia compared with pentastarch.
