Potential founction of γδT lymphocytes for cellular immunotherapies in osteosarcoma
- VernacularTitle:γδT细胞在细胞免疫治疗骨肉瘤中的潜在作用
- Author:
Zhenguo CAO
- Publication Type:Journal Article
- Keywords:
Osteosarcoma;
Receptors,antigen,T-cell,gamma-delta;
Immunity,cellular;
Immuno-therapy
- From:
Journal of International Oncology
2008;35(5):388-391
- CountryChina
- Language:Chinese
-
Abstract:
γδT lymphocytes,a numerically small subset of T lymphocytes,have been shown to directly recognize protein antigens without restriction by polymorphic MHC class I or class Ⅱ molecules and their asso-ciated peptide ligands,secrete cytokines,kill tumor cells and display cytolytie activity against various tumors.In osteosarconla patients,γδT lymphocytes can recognize antigens expressed on the surface of osteosarcoma cells,lyse and kill tumor cells.Combined with converntional chemotherapy and surgery,the new γδT lympho-cytes-based cell immunotherapy of osteosarcoma can increase the survival rate greatly.
