Study in HGF/c-Met pathway and its association with hepatocellular carcinoma and cholangiocarcinoma
- VernacularTitle:HGF/c-Met通路及其与肝癌和胆管癌的相关研究
- Author:
Xiucheng XUE
- Publication Type:Journal Article
- Keywords:
Hepatocyte growth factor;
Receptor protein-tyrosine kinases;
Liver neoplasms;
Bile duct neoplasms
- From:
Journal of International Oncology
2008;35(10):780-783
- CountryChina
- Language:Chinese
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Abstract:
Over-activation of HGF/c-Met plays an important role in the evolution process of tumor. It has been demonstrated HGF/c-Met is overexpressed in hepatocellular carcinoma and cholangiocarcinoma, and it participates directly or indirectly in the progress of tumor genesis, invasion and metastasis, as well as has significantly correlation with prognosis. Recently, blocking HGF/c-Met pathway to prevent tumor development and metastasis has become a focus in anti-tumor studies.
