A Cytogenetic Study of 130 Couples with Recurrent Spontaneous Abortion.
- Author:
Kyung A LEE
1
;
Ki Jin OH
;
Kap Jun YOON
Author Information
1. Departmemt of Clinical Pathology, Yonsei University Wonju College of Medicine, Wonju, Korea.
- Publication Type:Original Article
- Keywords:
Recurrent spontaneous abortion;
Chromosomal abnormality;
Stillborn fetus or malformed live child
- MeSH:
Abortion, Habitual;
Abortion, Spontaneous*;
Child;
Chromosome Aberrations;
Culture Techniques;
Cytogenetic Analysis;
Cytogenetics*;
Family Characteristics*;
Female;
Fetus;
Humans;
Lymphocytes;
Male;
Metaphase;
Pregnancy
- From:Korean Journal of Clinical Pathology
1998;18(3):476-479
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Chromosomal aberration of a couple can lead to recurrent miscarriage and it has been accounted for 2-10% of recurrent spontaneous abortions in the Caucasian population. The purpose of this study is to evaluate the frequency of chromosomal abnormalities in couples having fetal losses. We also attempted to define the relationship of those chromosome rearrangements with the presence or absence of stillborn fetus or malformed live child. METHODS: A total of 130 couples with two or more spontaneous abortions were studied. Chromosome studies were performed on metaphases using standard peripheral lymphocyte culture technique. RESULTS: Ten (7.7%) chromosomal abnormalities were detected, 7 (5.4%) in women and 3 (2.3%) in men. The chance of finding chromosomal abnormality in couples with stillborn fetus or malformed live child was higher than in couples with spontaneous abortions but no other adverse event, but the difference was not statistically significant. CONCLUSIONS: Cytogenetic analysis was indicated in couples with recurrent spontaneous abortions. The chance of chromosomal abnormality in couples with stillborn fetus or malformed live child was higher.
