The correlation between plasma calprotectin and neutrophil count in patients with aggressive periodontitis

VernacularTitle:侵袭性牙周炎患者血浆钙结合蛋白与血液中性粒细胞数相关性的研究
Author: Xiaojun SUN ¹ ; Huanxin MENG ; Dong SHI ; Zhibin CHEN
Author Information

1. 山西医科大学第一医院口腔科
Keywords: Aggressive periodontitis; Calcium-binding proteins; Neutrophil
From: Chinese Journal of Stomatology 2014;49(11):649-651
CountryChina
Language:Chinese
Abstract: Objective To measure the levels of plasma calprotectin in aggressive periodontitis (AgP) patients and to analyze the relationship between the plasma calprotectin and neutrophil count.Methods Venous blood samples were collected from 61 AgP patients and 48 periodontally healthy controls.Clinical examination consisted of bleeding index(BI),probing depth(PD),attachment loss measurements(AL) and percentage of severe sites.Plasma level of calprotectin was determined by enzyme-linked immunosorbent assay.Results The plasma concentrations of calprotectin in AgP patients [(2.1 ± 1.1) mg/L] were significantly higher than those in healthy controls[(1.5 ± 0.6) mg/L] (P＜0.01).The plasma concentration of calprotectin in AgP patients was positively correlated with BI (r=0.271,P=0.035),PD(r=0.437,P=0.000),AL(r=0.450,P=0.000) and percentage of severe sites(r=0.423,P=0.001).While the neutrophil count was also positively correlated with the plasma concentrations of calprotectin in AgP patients (r=0.380,P=0.004).Conclusions AgP may have impact on the elevation of plasma level of calprotectin.