Impact of gender on lipoprotein-associated phospholipase A2 activity and association with known cardiovascular risk factors
10.3760/cma.j.issn.0253-3758.2013.11.014
- VernacularTitle:脂蛋白相关磷脂酶A2活性水平的性别差异及其与心血管病危险因素的关系
- Keywords:
Cardiovascular diseases;
Risk factors;
Sex factors;
Phospholipases A
- From:
Chinese Journal of Cardiology
2013;41(11):962-967
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the impact of gender on lipoprotein-associated phospholipase A2 (Lp-PLA2) activity and association with known cardiovascular risk factors.Methods Participants in this study were recruited from Beijing sub-cohort from the Chinese Multi-provincial Cohort Study (CMCS) database.A total of 1471 participants with complete laboratory data were included in the study (688 male).Lp-PLA2 activity was determined by colorimetric assay kit.Lp-PLA2 activity level and correlation between Lp-PLA2 activity and known risk factors were compared between men and women.Results (1) Lp-PLA2 activity was higher in males than in females [(22.73 ±8.52) nmol· min-1 · ml-1 vs.(20.01 ±8.06) nmol · min-1 · ml-1,P ＜ 0.01].(2) Age,waist circumference,systolic blood pressure,diastolic blood pressure and the prevalence of hypertension were higher in males than in females,while total cholesterol,low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were higher in females than in males(P ＜ 0.05 or P ＜ 0.01).(3)Pearson correlation showed that Lp-PLA2 activity was correlated with lipids (total cholesterol,LDL-C,HDL-C,and triglyceride),blood pressure (systolic blood pressure and diastolic blood pressure),and adiposity associated parameters (waist circumference and body mass index) in males(all P ＜0.01) and was correlated with lipid level (total cholesterol,LDL-C,HDL-C,and triglyceride) and age in females(P ＜ 0.05 or P ＜ 0.01).Correlations with variables associated with obesity or blood pressure in females were much weaker than those in males (in females,r =0.02-0.08 ; in males,r =0.10-0.16).(4) After adjustment for age,waist circumference,systolic blood pressure,glucose,LDL-C,HDL-C,triglyceride and high sensitivity C-reactive protein by multiple logistic regression model,Lp-PLA2 activity was still significantly higher in males than in females (OR =1.72,95％ confidence interval =1.34-2.21,P ＜ 0.01).Conclusions Lp-PLA2 activity and association with known cardiovascular risk factors differed in males and females.The gender difference in Lp-PLA2 activity still presents after adjustment for known cardiovascular risk factors in this cohort.
