Biopharmaceutics classification system of Chinese materia medica of berberine in Gegen Qinlian decoction.
10.19540/j.cnki.cjcmm.20170223.001
- Author:
Yang LIU
1
;
Mei-Ling ZHU
1
;
Hui-Juan SUN
1
;
Zi-Yu WANG
1
;
Jiang-Peng CHEN
1
;
Yue-Liu DONG
1
;
Ling DONG
1
Author Information
1. Beijing University of Chinese Medicine, Beijing 100102, China.
- Publication Type:Journal Article
- Keywords:
CMMBCS;
Gegen Qinlian decoction;
berberine;
intestinal permeability;
solubility
- From:
China Journal of Chinese Materia Medica
2017;42(8):1545-1550
- CountryChina
- Language:Chinese
-
Abstract:
One of the top-level researches of biopharmaceutics classification system of Chinese materia medica (CMMBCS) is the study on single component in compound Chinese medicine. The medicines shall be classified according to its solubility and intestinal permeability, as well as the ascending degree in multicomponent environment. Based on above, we chose berberine as the main object to explore the change rules of its solubility and intestinal permeability in Gegen Qinlian decoction. Shaking flask-HPLC was used to detect the solubility changes of berberine in compounds. The qualitative investigation of berberine in intestinal absorption was measured by everted gut sac, and the quantitative research of berberine in intestinal absorption was measured by single-pass intestinal perfusion experiment, while the qualitative and quantitative research of berberine absorption into blood was measured by in intestinal perfusion with venous sampling experiment.
