Recent progress of mitochondrial quality control in ischemic heart disease and its role in cardio-protection of vagal nerve.
- Author:
Run-Qing XUE
1
;
Man XU
1
;
Xiao-Jiang YU
1
;
Long-Zhu LIU
1
;
Wei-Jin ZANG
2
Author Information
1. Department of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
2. Department of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China. zwj@xjtu.edu.cn.
- Publication Type:Journal Article
- From:
Acta Physiologica Sinica
2017;69(5):579-586
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic heart disease (IHD) is the life-threatening cardiovascular disease. Mitochondria have emerged as key participants and regulators of cellular energy demands and signal transduction. Mitochondrial quality is controlled by a number of coordinated mechanisms including mitochondrial fission, fusion and mitophagy, which plays an important role in maintaining healthy mitochondria and cardiac function. Recently, dysfunction of each process in mitochondrial quality control has been observed in the ischemic hearts. This review describes the mechanism of mitochondrial dynamics and mitophagy as well as its performance linked to myocardial ischemia. Moreover, in combination with our study, we will discuss the effect of vagal nerve on mitochondria in cardio-protection.
