HBsAg level and clinical course in patients with chronic hepatitis B treated with nucleoside analogue: five years of follow-up data.
10.3350/cmh.2013.19.4.409
- Author:
Jeong Han KIM
1
;
Yun Jung CHOI
;
Hee Won MOON
;
Soon Young KO
;
Won Hyeok CHOE
;
So Young KWON
Author Information
1. Digestive Disease Center, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea. 93haan@hanmail.net
- Publication Type:Original Article
- Keywords:
HBsAg;
Chronic hepatitis B;
Lamivudine;
Entecavir;
Resistance
- MeSH:
Adult;
Aged;
Antiviral Agents/*therapeutic use;
DNA, Viral/blood;
Drug Resistance, Viral/genetics;
Female;
Follow-Up Studies;
Guanine/*analogs & derivatives/therapeutic use;
Hepatitis B Surface Antigens/*blood;
Hepatitis B, Chronic/*drug therapy;
Humans;
Lamivudine/*therapeutic use;
Male;
Middle Aged;
Retrospective Studies
- From:Clinical and Molecular Hepatology
2013;19(4):409-416
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Quantification of the hepatitis B surface antigen (HBsAg) is increasingly used to determine the treatment response in patients with chronic hepatitis B (CHB). However, there are limited data about the clinical implications of Quantification of HBsAg long-term nucleoside analogue treatment for CHB. We investigated the clinical correlation between HBsAg level and clinical course in patients with CHB who are treated long-term with nucleoside analogues. METHODS: Patients with CHB who started lamivudine or entecavir monotherapy before June 2007 were enrolled. HBsAg was quantified at baseline, at 6 months, and at 1, 2, 3, 4, and 5 years of treatment. We compared data between the groups according to the presence or absence of a virological response (VR) and resistance. RESULTS: Forty-eight patients were analyzed. There was no definite reduction in HBsAg level during the early period of treatment; differences in HBsAg levels between baseline and each time point were significant only at 5 years (P=0.028). In a subgroup analysis, this difference was significant only in non-resistant patients at 5 years (P=0.041). CONCLUSIONS: There was no definite decrease in the HBsAg level during the early period of nucleoside analogue treatment, with long-term treatment being required to observe a significant reduction.
