The mechanism of inhibitory effect on parotid gland secretion with local injection of botulinum toxin type A in the rat
10.3760/cma.j.issn.1002-0098.2009.01.011
- VernacularTitle:A型肉毒素对腮腺分泌功能影响的研究
- Author:
Wei-Dong WEN
1
;
Fang YUAN
;
Yi-Ping HOU
Author Information
1. 西北民族大学医学院
- Keywords:
Botulinum toxins;
Parotid gland;
Sialorrhea
- From:
Chinese Journal of Stomatology
2009;44(1):38-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the mechanism of inhibitory effect of botulinum toxin type A (BTX-A)on parotid gland secretion.Methods Female Wistar rats(n=18)were randomly divided into saline injection group(n=6)and BTX-A injection group(n=12),respectively.0.1 ml of saline was injected into left parotid gland and 2.5 U of BTX-A injected into right parotid gland.Rats were sacrificed at day 7,12 and 35 post-injections respectively for morphology and vasoactive intestinal polypeptide(VIP)immunoreactivity of parotid gland.Results Following BTX-A injection,some atrophic cells and reduction of number of VIP-immunoreactive(VIP-IR)fibers were found in gland and tube at day 7(P＜0.05);at day 12,there was more obvious reduction of VIP-IR fibers around tube and vessels and atrophy of cells in BTX-A injection gland than saline injection gland(P＜0.001);at day 35,the glandular cells and VIP-IR fibers were similar to saline injection group.Conclusions BTX-A is effective for temporary elimination of hyperfunctioning sialorrhea via inhibition of VIP release which plays a key role in modulation of parotid glands secretion.
