Synthesis and antibacterial and antifungal effect of 5-(5' nitro 2' furfuryliden)-2 thioxo-4 thiazolidinone and derivatives
- Author:
Hai Thanh Dinh
- Publication Type:Journal Article
- Keywords:
synthesis
- MeSH:
Chemical synthesis;
Antibacteria Agents;
Antifungal Agents
- From:Pharmaceutical Journal
1999;282(10):13-16
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Nitration of furfural give 5-nitro furfural diacetat (NFD). By the condensation of NFD with 2 - thioxo 4 thiatolidinone, derivative I was formed. Compound I underwent Mannich reaction and gave II-IX with formaldehyde (36% aqueous solution) and various amines. The structure of synthesized compounds were characterized by UV and IR. The obtained products were tested for biological activities such as antibacterial and antifungal. All synthesized compounds showed a high antibacterial activity on 8 strains of bacteria and a high antifungal activity against Candida albicans. Among these, derivative I and VIII showed the highest activity.
