Investigation of a compound, compatibility of Rhodiola crenulata, Cordyceps militaris, and Rhum palmatum, on metabolic syndrome treatment. IV--Improving liver lipid accumulation.
- Author:
Juan LI
1
;
Xiao-Lin ZHANG
;
Yu-Ying LIU
;
Ling CHEN
;
Jin-Ying TIAN
;
Jing-Yan HAN
;
Pei-Cheng ZHANG
;
Fei YE
Author Information
1. Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Cordyceps;
chemistry;
Disease Models, Animal;
Drugs, Chinese Herbal;
administration & dosage;
Fatty Liver;
drug therapy;
metabolism;
Humans;
Insulin Resistance;
Lipid Metabolism;
drug effects;
Liver;
drug effects;
metabolism;
Male;
Metabolic Syndrome;
drug therapy;
metabolism;
Mice;
Mice, Inbred C57BL;
Non-alcoholic Fatty Liver Disease;
Rheum;
chemistry;
Rhodiola;
chemistry
- From:
China Journal of Chinese Materia Medica
2013;38(11):1789-1794
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the effects of a compound (FF16), compatibility of Rhodiola crenulata, Cordyceps militaris, and Rhum palmatum, on non-alcoholic fatty liver disease in IRF mice induced by high fat diet H&E stain was processed to evaluate the lipid accumulation in liver, and the dynamic microcirculation observation system was applied to determine hepatic microcirculation of IRF mice. Western blot was performed to evaluate IRS-2, HSL and ppar-alpha expression in liver. The results demonstrate that FF16 significantly decreased the liver lipid index and improved liver steatosis in IRF mice. Furthermore, FF16 could ameliorate hepatic microcirculation disturbance in IRF mice through enhancing RBC velocity and shear rates by 62.5% and 49.7%, increasing sinusoids perfusion by 70.0%, inhibiting adhered leukocytes in IRF mice. The abnormal expressions of IRS-2 and HSL were both reversed by the administration of FF16. In conclusion, FF16 could improve non-alcoholic fatty liver disease in IRF mice by improving insulin sensitivity, regulating lipid metabolism and improving microcirculation disturbance.
