Reduced Expression of PTEN Protein and Its Prognostic Significance in the Gastrointestinal Stromal Tumor
10.1007/s11596-010-0206-1
- Author:
ZHANG YONGHONG
1
;
YU DONGDONG
;
LI XIAOLAN
;
HU JUNBO
;
GONG JIANPING
Author Information
1. Tongji Cancer Research Institute, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
- Keywords:
gastrointestinal stromal tumor;
PTEN;
prognosis
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2010;30(2):165-169
- CountryChina
- Language:Chinese
-
Abstract:
Little is reported about the role of PTEN gene in the progression and prognosis of GISTs.This study examined the clinical implications of the tumor suppressor gene PTEN as a prognostic factor in the GISTs.Immunohistological staining and immunoblotting were employed to examine the PTEN protein expression,and its association with clinical measures.Clinicopathological features were reviewed by a retrospective examination of medical records.Reduced PTEN expression was significantly associated with tumor diameter,mitotic figure count,metastasis and pathological stage of tumor(P<0.05),and was not correlated with age,gender and tumor location(P>0.05).The 3-year survival rate of the patients with reduced PTEN expression was significantly lower than those with high PTEN expression(P<0.01).These results suggest that the expression of PTEN gene was significantly linked with the progression and metastasis of GISTs and it is an independent prognostic factor.
