Elicitation of mismatch negativity and its influence from stimuli deviant in the healthy youth
10.3760/cma.j.issn.1673-0860.2009.03.002
- VernacularTitle:健康青年人失匹配负波的提取及刺激偏差对波形的影响
- Author:
Zhuo CHEN
1
;
Ning-Yu WANG
;
Jin-Lan LI
;
Zhong-Hai XIN
;
Xiao-Hui WEN
Author Information
1. 首都医科大学附属北京朝阳医院
- Keywords:
Evoked potentials;
Auditory perception;
Reaction time;
Acoustic stimulation
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2009;44(3):182-187
- CountryChina
- Language:Chinese
-
Abstract:
Objective To work out the elicitation plan, obtain the mismatch negativity(MMN) and get out the laboratory normal value as well as to study the influence to MMN from the deviation of auditory stimuli. Methods Hearing test of the tone burst stimulation was performed on 21 healthy young volunteers according to oddball stimulation sequence. Each subject was performed two kinds of auditory stimuli including frequency deviant stimuli and intensity deviant stimuli, and of each one included three series of stimulation. MMN was gained by subtracting the ERP of deviant stimuli from the ERP of standard stimuli. The latency and amplitude of each MMN were recorded, and then the effect of the deviant extent for MMN was analyzed. Results By this setup the MMN of normal young people was recorded and normal value of latency and amplitude of MMN were got. In the group of frequency deviant stimuli, the MMN latency [(155.81 ± 29.08) ms], if the frequency was up to 2000 Hz, was shorter than that when the frequency deviance was 1000 Hz[(182.89±45.85) ms, (183.32±43.33) ms] (P =0.033, 0.030) ; when the deviant extent were the same, the latency had no obvious difference if changing the frequency of the standard and deviant stimuli (P = 0.973) ; the M M N amplitude of three groups [(3.85±2.22)μN, (2.90±2.05) μV, (2.66 ± 2. 12)μV] had no obvious difference among them (P > 0.05). In the group of intensity deviant stimuli, the MMN latency [(157.04±34.87)ms], if the frequency was up to 20 dB, was shorter (P = 0.025, 0.017) than that when the intensity deviance was 10 dB [(184.46 ± 38.05) ms, (186.24 ± 42.36)ms]. When the deviant extent were the same, the latency had no obvious difference(P =0.882) if changing the intensity of the standard and deviant stimuli but only group 4 and group 6 [(3.41 ± 1.64) μV, (2.37 ± 1.47) μV] were different in evidence (P = 0.031) while the others had no obvious difference (P = 0.524, 0.122). Conclusions MMN was only related to the difference between standard stimuli and deviant stimuli, but there was no relationship between MMN and the notice, which indicate that MMN could objectively reflect the capability of brain to detect the change of stimuli. MMN is the representation of brain high-level sensory function.
