Cytocompatibility of PBS/PLA blend as the sternal fixation material.
- Author:
Kun HUA
1
,
2
;
Xiao-wei WANG
;
Wei ZHANG
;
Jian ZHOU
;
Xiu-bin YANG
;
Jun-hui JI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Biocompatible Materials; Cell Line; Cell Survival; Lactic Acid; chemical synthesis; Materials Testing; Mice; Polymers; chemical synthesis
- From: Journal of Southern Medical University 2010;30(7):1501-1508
- CountryChina
- Language:Chinese
-
Abstract:
UNLABELLEDTo evaluate biocompatibility and cytotoxicity of PBS/PLA blend as the material for sternal fixation.
METHODSL929 cell line was used to assess the cytotoxicity and cytocompatibility of PBS/PLA blend by incubation of the cells with the aqueous extract of the material for 3 days. The cytocompatibility of the material was evaluated by observing the proliferation of the cells cultured on the surface of the material. The proliferation of the cells cultured on the surface of the material was compared with that of the cells cultured on medical polyethylene and polyvinyl chloride to assess the cytotoxicity of the material.
RESULTSL929 cells showed no morphological changes after a 3-day incubation with the aqueous extract of the material. The cells cultured on the surface of the blend material exhibited better proliferative activity than those cultured on medical polyethylene and polyvinyl chloride, demonstrating no obvious cytotoxicity of the material.
CONCLUSIONPBS/PLA blend material possesses excellent cytocompatibility and can be a promising biodegradable polymer for sternal fixation.
