T-bet/GATA-3 ratio is a surrogate measure of Th1/Th2 cytokine profiles and may be novel targets for CpG ODN treatment in asthma patients.
- Author:
Liang DONG
1
;
Ming CHEN
;
Qi ZHANG
;
Li-zheng LI
;
Xiao-qun XU
;
Wei XIAO
Author Information
1. Department of Pulmonary Disease, Qilu Hospital, School of Medicine, Shandong University, Jinan 250012, China. dl5506@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Adjuvants, Immunologic;
pharmacology;
Asthma;
blood;
Cells, Cultured;
Cytokines;
metabolism;
Enzyme-Linked Immunosorbent Assay;
methods;
Female;
GATA3 Transcription Factor;
genetics;
metabolism;
Humans;
Interferon-gamma;
metabolism;
Interleukin-13;
metabolism;
Interleukin-4;
metabolism;
Interleukin-5;
metabolism;
Leukocytes, Mononuclear;
cytology;
drug effects;
metabolism;
Male;
Oligodeoxyribonucleotides;
pharmacology;
Pulmonary Disease, Chronic Obstructive;
blood;
RNA, Messenger;
genetics;
metabolism;
Reverse Transcriptase Polymerase Chain Reaction;
methods;
Statistics as Topic;
T-Box Domain Proteins;
T-Lymphocytes, Helper-Inducer;
cytology;
drug effects;
metabolism;
Th1 Cells;
cytology;
drug effects;
metabolism;
Th2 Cells;
cytology;
drug effects;
metabolism;
Transcription Factors;
genetics;
metabolism
- From:
Chinese Medical Journal
2006;119(16):1396-1399
- CountryChina
- Language:English
