Role of NF-κB inhibitor in Acute Myeloid Leukemia.
- Author:
Wei-Li WANG
1
;
Qiao-Zhu XU
1
;
Xiao-Huan MU
1
;
Le WANG
1
;
Li-Yan ZHANG
1
;
Jing XU
1
;
Ying-Dai GAO
1
;
Tao CHENG
1
;
Wei-Ping YUAN
2
Author Information
- Publication Type:Journal Article
- From: Journal of Experimental Hematology 2016;24(6):1622-1626
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the role of NF-κB inhibitor in occurence and development of AML.
METHODSAML and normal bone marrow samples were collected from 8 AML patients and 8 normal persons. The expression of NF-κB signaling pathway genes was detected by NF-κB PCR array. Then, AML mouse model was constructed to test the role of NF-κB inhibitor in AML.
RESULTSThe NF-κB signal pathway was activated in AML patients. The up-regulated genes, EDARADD, TNFSF14, could activate the NF-κB signal pathway, IL6 could regulate the inflammatory signal. The down-regulated genes, TNFRSF 10B, TNFRSF1A, could lead to cell apoptosis. the AML mouse model was constructed successfully. Then administration of NF-κB inhibitor reduced the inhibition of leukemia niche to the normal hematopoietic stem cells (HSCs), promoted the HSC to enter into cell cycle.
CONCLUSIONThe NF-κB signal pathway is activated in AML cells. AML mouse model is constructed successfully. NF-κB inhibitor has a potential to treat AML and promotes the HSC to enrter into cell cycle.
