OBJECTIVETo explore the clinical significance of WT1 expression level in patient with AML non-M3,understand the biological characteristics of Auerand CD34AML and its effects on first induced remission rate and prognosis.

METHODSThe RQ-PCR was used to detect the WT1 expression levels in 92 patients suffering AML non-M3; the relationship between the CR1 and OS was analysed and the differences of CR1 and OS in AML with Auerand Auer,CD34and CD34were compared.

RESULTSAML with WT1 high expression level at first visit had quite lower CR1 (P<0.05). AML with CD34had quite lower CR1 (P<0.05). Compared with Auerpatients, CR1 of AuerCML patients was higher (P<0.05), the OS of AML patients with WT1 high expression level was lower than that of the AML patients with low expression level of WT1, and with significant differences (P<0.05), the OS of AML patients with CD34was lower than that of AML patients with CD34, and with significant differences (P<0.05). There was no obvious difference in OS between the AML patients with Auerand Auer.

CONCLUSIONHigh expression level of WT1 and CD34in AML patients suggests the poor prognosis. The Auer positive only relats with CR1, and does not relate with OS.