Clinical Efficacy of Autologous Hematopoietic Stem Cell Transplantation Using Tumor-ablative Conditioning Regimen for Patients with Refractory/Relapsed Non-Hodgkin's Lymphoma.
- Author:
Xue-Liang YANG
1
;
Ya-Mei WU
1
;
Yong-Bin CAO
1
;
Xiao-Hong LI
1
;
Li-Xin XU
1
;
Zhou-Yang LIU
1
;
Bei LIU
1
;
Bei YAN
1
;
Song-Wei LI
1
;
Wan-Ming DA
2
;
Xiao-Xiong WU
3
Author Information
- Publication Type:Journal Article
- From: Journal of Experimental Hematology 2016;24(6):1743-1747
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the safety and effectiveness of autologous hematopoietic stem cell transplantation (auto-HSCT) using tumor-ablative conditioning regiment for patients with refractory/relapsed non-Hodgkin's lymphoma.
METHODSThe clinical data of 16 patients with refractory/relapsed non-Hodgkin's lymphoma received above-mentioned therapeutic regimen from January 2013 to July 2015 was analyzed retrospectively, and conditioning-related toxicity, engraftment, infection, relapse and survival rate were evaluated.
RESULTSNo conditioning-related organs' failure and mortality were found. Only 1 patient had not been engrafted, and the engraftment rate was 93.7%. The incidence of serious infection was 31.2%. The median follow-up was 20.5(1-30) months, and 3 patients died, out of them 2 patients died of relapse. Two year overall survival (OS) , disease-free survival (DFS) and relapse rates were 80.2%, 74.5% and 20.6% respectively.
CONCLUSIONAuto-HSCT using tumor-ablative conditioning regimen is safe and effective for patients with refractory/relapsed non-Hodgkin's lymphoma, and it possess a certain effect for reducing disease relapse after transplantation.
