Interactions between dopamine receptor and NMDA/type A γ-aminobutyric acid receptors.
- Author:
Hui-Ying CHEN
1
;
Ting-Jia WEI
1
;
Jing-Jin WENG
1
;
Jiang-Yuan QIN
1
;
Xi HUANG
1
;
Ji-Ping SU
2
,
3
Author Information
1. Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
2. Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. ymsu2@
3. com.
- Publication Type:Journal Article
- MeSH:
Animals;
Dopamine;
Neurotransmitter Agents;
Receptors, Dopamine;
Receptors, GABA-A;
Receptors, N-Methyl-D-Aspartate;
Signal Transduction;
Synapses
- From:
Acta Physiologica Sinica
2016;68(2):185-193
- CountryChina
- Language:Chinese
-
Abstract:
Type A γ-aminobutyric acid receptors (GABAAR) and N-methyl-D-aspartate receptors (NMDAR) are the major inhibitory and excitatory receptors in the central nervous system, respectively. Co-expression of the receptors in the synapse may lead to functional influence between receptors, namely receptor interaction. The interactions between GABAAR and NMDAR can be either positive or negative. However, the mechanisms of interaction between the two receptors remain poorly understood, and potential mechanisms include (1) through a second messenger; (2) by receptors trafficking; (3) by direct interaction; (4) by a third receptor-mediation. Dopamine is the most abundant catecholamine neurotransmitter in the brain, and its receptors, dopamine receptors (DR) can activate multiple signaling pathways. Earlier studies on the interaction between DR and GABAAR/NMDAR have shown some underlying mechanisms, suggesting that DR could mediate the interaction between GABAAR and NMDAR. This paper summarized some recent progresses in the studies of the interaction between DR and NMDAR/GABAAR, providing a further understanding on the interaction between NMDAR and GABAAR mediated by DR.
